Phenyl chloroformate → HCID 59379902, compound

Participants

Reaction Steps

Methyl 2-(4-aminophenyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylate (400 mg) was dissolved in dioxane (10 mL) and sodium bicarbonate (154 mg) and phenylchloroformate (0.154 mL) added dropwise. The mixture was stirred at RT for 16 hours then the dioxane removed under reduced pressure and the residue partitioned between water (50 mL) and ethyl acetate (50 mL). The organic layer was dried over magnesium sulphate, filtered and evaporated to give the desired material as a brown foam (624 mg).

Provenance & Evidence