Methanol → HCID 59380147, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-Aminophenyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidine-4-carboxylic acid (1.15 g) was dissolved in methanol (15 mL), sulfuric acid (0.01 mL) was added and the reaction was heated at 80° C. for 24 h. A small quantity of activated molecular sieve 4A was added to the reaction and stirred for 2 h. The reaction was filtered, vacuumed to dryness then suspended in ethyl acetate (250 mL) and washed once with a saturated solution of sodium bicarbonate (250 mL). The organic layer was filtered, dried over magnesium sulphate and vacuumed to dryness to give the desired material as a brown solid (405 mg).

Provenance & Evidence