Triethylamine → 1-[4-[4-[(3S)-3-Methylmorpholin-4-yl]-6-(methylsulfonyloxymethyl)pyrimidin-2-yl]phenyl]-3-(1,2-oxazol-3-yl)urea

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Reaction Steps

1-[4-[4-(Hydroxymethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]-3-(1,2-oxazol-3-yl)urea (300 mg) was partially dissolved in DCM (10 mL) and triethylamine (0.153 mL) and the solution was cooled to 0° C. Methane sulfonyl chloride was added (0.086 mL) and the reaction was stirred for 45 mins at RT. The reaction was then washed with water (2 mL) and dried over magnesium sulphate. The solution was vacuumed to dryness to give the desired material as a yellow solid.

Provenance & Evidence