Methylamine → 3-Methyl-1-[5-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidin-2-yl]-1,3-thiazol-2-yl]urea

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Reaction Steps

A solution of phenyl N-[5-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-methylsulfonylpropan-2-yl)pyrimidin-2-yl]-1,3-thiazol-2-yl]carbamate (200 mg, 0.39 mmol), methyl amine (1.5 mmol) and triethylamine (0.163 mL, 1.16 mmol) in NMP (3 mL) was heated at 70° C. for 2 hours. The mixture was chromatographed on silica, eluting with 0-5% methanol in ethyl acetate to give the desired material.

Provenance & Evidence