Water → HCID 59380116, compound

Participants

Reaction Steps

Phenyl chloroformate (0.029 mL, 0.23 mmol) was added to a solution of 4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(pyridin-4-ylsulfonylmethyl)pyrimidin-2-yl]aniline (0.097 g, 0.23 mmol) and sodium bicarbonate (0.029 g, 0.34 mmol) in dioxane at RT. The resulting slurry was stirred at RT for 2 hours. Additional phenyl chloroformate (2×0.005 mL) was added to drive the reaction to completion. Water was then added to the reaction and the solid filtered, and dried in a vacuum oven to give the desired material as an off-white solid (0.098 g).

Provenance & Evidence