HCID 59380114, compound → HCID 59380155, compound

HRID 2353713Notes

Reaction equation

[CH:1]1([S:4]([C:7]([C:10]2[CH:15]=[C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][C@@H:17]3[CH3:22])[N:13]=[C:12]([C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:38])OC4C=CC=CC=4)=[CH:25][CH:24]=3)[N:11]=2)([CH3:9])[CH3:8])(=[O:6])=[O:5])[CH2:3][CH2:2]1.C1(S(C[C:46]2C=C(N3CCOC[C@@H]3C)N=C(C3C=CC(NC(=O)OC4C=CC=CC=4)=CC=3)[N:47]=2)(=O)=O)CC1>>[CH:1]1([S:4]([C:7]([C:10]2[CH:15]=[C:14]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][C@@H:17]3[CH3:22])[N:13]=[C:12]([C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30]([NH:47][CH3:46])=[O:38])=[CH:25][CH:24]=3)[N:11]=2)([CH3:8])[CH3:9])(=[O:5])=[O:6])[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 59380114HCID 59380114, compound

HCID 59380196HCID 59380196, compound

Product 1

HCID 59380155HCID 59380155, compound

Procedure

The following compounds were made in an analogous fashion from either phenyl N-[4-[4-(2-cyclopropylsulfonylpropan-2-yl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate or phenyl N-[4-[4-(cyclopropylsulfonylmethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate and the appropriate amine.

Sources & evidence

ORD record: ord-50aa8dcffaf247ec826630da8ee6d106
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750003B2

Reaction notes

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