Phenyl chloroformate → HCID 59380196, compound

Participants

Reaction Steps

Phenyl chloroformate (0.315 mL, 2.50 mmol) was added dropwise to 4-[4-(cyclopropylsulfonylmethyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline (972 mg, 2.50 mmol) and sodium bicarbonate (315 mg, 3.75 mmol) in dioxane (20 mL). The resulting suspension was stirred at RT for 2 hours. The reaction mixture was evaporated to dryness and redissolved in ethyl acetate (100 mL) and washed with water (100 mL). The organic layer was dried (MgSO4), filtered and evaporated to afford the desired material (1.35 g).

Provenance & Evidence