Water → HCID 59380227, compound

Participants

Reaction Steps

Phenyl chloroformate (0.046 mL, 0.36 mmol) was added to 2-[[2-(4-aminophenyl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-4-yl]methylsulfonyl]ethanol (0.143 g, 0.36 mmol) and sodium bicarbonate (0.046 g, 0.55 mmol) in dioxane (20 mL) at RT under air. The resulting slurry was stirred at RT for 2 hours. Water was added and the mixture extracted with DCM three times. The combined organics were dried (MgSO4), filtered and concentrated in vacuo to give the desired material as a yellow solid (0.228 g).

Provenance & Evidence