HCID 59380011, compound → HCID 59379938, compound

HRID 2353720Notes

Reaction equation

HRID 2353720 reaction equation
[CH:1]([S:4]([CH2:7][C:8]1[CH:13]=[C:12]([N:14]2[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]2[CH3:20])[N:11]=[C:10]([C:21]2[CH:26]=[CH:25][C:24]([NH:27][C:28](=O)[O:29]C3C=CC=CC=3)=[CH:23][CH:22]=2)[N:9]=1)(=[O:6])=[O:5])([CH3:3])[CH3:2].C[C@H]1COCCN1C1C=C(C(S(C(C)C)(=O)=O)(C)C)N=C([C:59]2[CH:64]=[CH:63][C:62]([NH:65]C(=O)OC3C=CC=CC=3)=CC=2)N=1>>[CH:62]1([NH:65][C:28](=[O:29])[NH:27][C:24]2[CH:25]=[CH:26][C:21]([C:10]3[N:11]=[C:12]([N:14]4[CH2:19][CH2:18][O:17][CH2:16][C@@H:15]4[CH3:20])[CH:13]=[C:8]([CH2:7][S:4]([CH:1]([CH3:3])[CH3:2])(=[O:5])=[O:6])[N:9]=3)=[CH:22][CH:23]=2)[CH2:63][CH2:64][CH2:59]1

Participants

3

Reactant 2

HCID 59380011HCID 59380011, compoundHCID 59380068HCID 59380068, compound

Product 1

HCID 59379938HCID 59379938, compound

Procedure

The following compounds were made in an analogous fashion from either phenyl (4-{4-[(isopropylsulfonyl)methyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl}phenyl)carbamate or phenyl N-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-propan-2-ylsulfonylpropan-2-yl)pyrimidin-2-yl]phenyl]carbamate and the appropriate amine.

Sources & evidence

ORD record
ord-e513b42bb2584a80a813280f80cfdf23
Source dataset
uspto-grants-2010_07
Patent number
US07750003B2

Reaction notes

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