Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | HCID 59380080 | HCID 59380080 | — |
| Catalyst | HCID 178418476 | HCID 178418476 | — |
| Solvent | Dimethoxyethane ethanol water | HCID 86587095 | — |
| Product | HCID 59380063 | HCID 59380063 | — |
Reaction Steps
Dichlorobis(triphenylphosphine)palladium(II) (116 mg, 0.17 mmol) was added to 2-chloro-4-[(3S)-3-methylmorpholin-4-yl]-6-(2-propan-2-ylsulfonylpropan-2-yl)pyrimidine (1.2 g, 3.32 mmol), and sodium carbonate (5 mL, 10.00 mmol) in 18% DMF in a mixture of DME:water:ethanol (7:3:2) (20 mL). The resulting solution was stirred at 90° C. for 4 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07750003B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-5f0e6c66d361497ea2c84d2c2a7187cb |
|---|
| Source note | uspto-grants-2010_07 |
|---|
