Phenyl chloroformate → HCID 59380028, compound

Participants

Reaction Steps

Phenyl chloroformate (0.373 mL, 2.97 mmol) was added dropwise to 4-[4-(2-ethylsulfonylpropan-2-yl)-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]aniline (1.20 g, 2.97 mmol) and sodium bicarbonate (0.374 g, 4.45 mmol) in dioxane (25 mL) under nitrogen. The resulting suspension was stirred at RT for 2 hours. The reaction mixture was evaporated to dryness and partitioned between ethyl acetate (150 mL) and water (150 mL). The organic layer was dried (MgSO4), filtered and evaporated to give the desired material as a white solid (1.40 g).

Provenance & Evidence