HCID 59380129, compound → HCID 59379978, compound

HRID 2353741Notes

Reaction equation

[CH3:1][C@H:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[C:12]([CH2:14][S:15]([C:18]([CH3:21])([CH3:20])[CH3:19])(=[O:17])=[O:16])[N:11]=[C:10]([C:22]2[CH:27]=[CH:26][C:25]([NH:28][C:29](=O)[O:30]C3C=CC=CC=3)=[CH:24][CH:23]=2)[N:9]=1.[CH3:38][C@H:39]1COCC[N:40]1C1C=C(C(S(C(C)(C)C)(=O)=O)(C)C)N=C(C2C=CC(NC(=O)OC3C=CC=CC=3)=CC=2)N=1>>[CH2:39]([NH:40][C:29](=[O:30])[NH:28][C:25]1[CH:26]=[CH:27][C:22]([C:10]2[N:9]=[C:8]([N:3]3[CH2:4][CH2:5][O:6][CH2:7][C@@H:2]3[CH3:1])[CH:13]=[C:12]([CH2:14][S:15]([C:18]([CH3:20])([CH3:19])[CH3:21])(=[O:17])=[O:16])[N:11]=2)=[CH:23][CH:24]=1)[CH3:38]

Participants

Reactant 2

HCID 59380129HCID 59380129, compound

HCID 59380143HCID 59380143, compound

Product 1

HCID 59379978HCID 59379978, compound

Procedure

The following compounds were made in an analogous fashion from either phenyl N-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(tert-butylsulfonylmethyl)pyrimidin-2-yl]phenyl]carbamate or phenyl N-[4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-tert-butylsulfonylpropan-2-yl)pyrimidin-2-yl]phenyl]carbamate and the appropriate amine.

Sources & evidence

ORD record: ord-889a96fbbeb14aca8a0596038f295fd9
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750003B2

Reaction notes

Loading…