HCID 59380121, compound → HCID 59380050, compound

HRID 2353745Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([S:9]([CH2:12][C:13]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][C@@H:20]3[CH3:25])[N:16]=[C:15]([C:26]3[CH:31]=[CH:30][C:29]([NH:32][C:33](=[O:41])OC4C=CC=CC=4)=[CH:28][CH:27]=3)[N:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1.FC1C=C(S([C:53]([C:56]2C=C(N3CCOC[C@@H]3C)N=C(C3C=CC(NC(=O)OC4C=CC=CC=4)=CC=3)[N:57]=2)(C)C)(=O)=O)C=C(F)C=1>>[F:1][C:2]1[CH:3]=[C:4]([S:9]([CH2:12][C:13]2[CH:18]=[C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][C@@H:20]3[CH3:25])[N:16]=[C:15]([C:26]3[CH:31]=[CH:30][C:29]([NH:32][C:33]([NH:57][CH2:56][CH3:53])=[O:41])=[CH:28][CH:27]=3)[N:14]=2)(=[O:11])=[O:10])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

Reactant 2

HCID 59380121HCID 59380121, compound

HCID 59380178HCID 59380178, compound

Product 1

HCID 59380050HCID 59380050, compound

Procedure

The following compounds were made in an analogous fashion from either phenyl N-[4-[4-[(3,5-difluorophenyl)sulfonylmethyl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate or phenyl N-[4-[4-[2-(3,5-difluorophenyl)sulfonylpropan-2-yl]-6-[(3S)-3-methylmorpholin-4-yl]pyrimidin-2-yl]phenyl]carbamate and the appropriate amine.

Sources & evidence

ORD record: ord-bff5103a6b8949f78ce6106ab07dbc1f
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750003B2

Reaction notes

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