Phenyl chloroformate → HCID 59379979, compound

Participants

Reaction Steps

Phenyl chloroformate (0.432 mL, 3.44 mmol) was added to 4-[4-[(3S)-3-methylmorpholin-4-yl]-6-(2-pyridin-2-ylsulfonylpropan-2-yl)pyrimidin-2-yl]aniline (1.3 g, 2.87 mmol) and sodium hydrogen carbonate (0.482 g, 5.73 mmol) in dioxane (20 mL) at RT. The resulting slurry was stirred at RT for 1 hour and then the reaction mixture was partitioned between ethyl acetate and water. The organic solution was dried (MgSO4) and concentrated under reduced pressure. The residue was chromatographed on silica, eluting with 0%-20% ethyl acetate in DCM, to give the desired material as a yellow dry film (1.62 g).

Provenance & Evidence