5-Aminosalicylic Acid → HCID 9943418, compound

HRID 2353768Notes

Reaction equation

HRID 2353768 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Cl)=[CH:16][CH:15]=1>>[CH3:12][O:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 699934-Methyloxybenzyl chloride

Product 1

HCID 9943418HCID 9943418, compoundYield 50%

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (1.00 g, 6.53 mmole) and 4-methoxybenzyl chloride (1.23 g, 7.84 mmole), 890 mg (50% yield) of 5-(4-methoxybenzyl)aminosalicylic acid was obtained as a white solid.: mp 205-206° C.

Workup

  1. customin Synthesis Example 1

Sources & evidence

ORD record
ord-b6c707706b12465cac3ac82622205956
Source dataset
uspto-grants-2010_07
Patent number
US07750045B2

Reaction notes

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