5-Aminosalicylic Acid → HCID 7027806, compound

HRID 2353770Notes

Reaction equation

HRID 2353770 reaction equation
[NH2:1][C:2]1[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=1.[N+:12]([C:15]1[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=1)([O-:14])=[O:13]>>[N+:12]([C:15]1[CH:16]=[CH:17][C:18]([C:19]([NH:1][C:2]2[CH:10]=[C:6]([C:7]([OH:9])=[O:8])[C:5]([OH:11])=[CH:4][CH:3]=2)=[O:20])=[CH:22][CH:23]=1)([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 85024-Nitrobenzoyl chloride

Product 1

HCID 7027806HCID 7027806, compoundYield 56%

Procedure

By following the similar procedure in Synthesis Example 1 by using 5-aminosalicylic acid (500 mg, 3.26 mmole) and 4-nitrobenzoyl chloride (700 mg, 3.77 mmole), 550 mg (56% yield) of 5-(4-nitrobenzoyl)aminosalicylic acid was obtained as a pale yellow solid.: mp 270-271° C.

Workup

  1. customin Synthesis Example 1

Sources & evidence

ORD record
ord-ad1baf8d74f249f38f04650c573a8f4c
Source dataset
uspto-grants-2010_07
Patent number
US07750045B2

Reaction notes

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