Dimethylformamide → HCID 68441321, compound

Participants

Reaction Steps

To a solution of 2-bromo-4-hydroxy-5-methoxy-N-acetyl benzylamine 3 (0.3 g, 1.1 mmol) in dry DMF (10 ml) dry K2CO3 (2 mol eq) and 3-chloro-1,2-dihydroxypropane (2 mol eq) were added. The mixture was refluxed for 6 hours, then the solvent was evaporated off under reduced pressure. After addition of water the aqueous layer was extracted with EtOAc (3×25 ml) and the organic phases were anhydrified over Na2SO4 and evaporated off under reduced pressure to furnish the title compound as pale yellow solid (0.35 g, 84% yield).

Provenance & Evidence