Potassium Carbonate → HCID 68443999, compound

Participants

Reaction Steps

Dry K2CO3 (2 mol eq) and 2-iodoethanol (2 mol eq) were added to a solution of 2-chloro-4-hydroxy-5-methoxy-N-acetyl benzylamine 3 (0.4 g, 1.46 mmol) in dry DMF (15 ml). The mixture was refluxed for 6 hours, then the solvent was evaporated off under reduced pressure. After addition of water the aqueous layer was extracted with EtOAc (3×25 ml) and the organic phases were anhydrified over Na2SO4 and evaporated under reduced pressure to furnish the title compound as pale yellow solid (0.38 g, 81% yield).

Provenance & Evidence