1-(5-Tert-butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea → HCID 22573874, compound

HRID 23538Notes

Reaction equation

HRID 23538 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:12])([CH3:11])[CH3:10])=[CH:5][C:4]=1[NH2:13].[NH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]([C:25]2[CH:26]=[CH:27][C:28]([CH2:31][N:32]3[CH2:37][CH2:36][O:35][CH2:34][CH2:33]3)=[N:29][CH:30]=2)=[CH:17][CH:16]=1.C(C1C=CC(OC)=C(N[C:49](NC2C3C(=CC=CC=3)C(OC3C=CN=C(C#N)N=3)=CC=2)=[O:50])C=1)(C)(C)C>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([Si:9]([CH3:12])([CH3:11])[CH3:10])=[CH:5][C:4]=1[NH:13][C:49]([NH:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[C:18]([C:25]2[CH:30]=[N:29][C:28]([CH2:31][N:32]3[CH2:33][CH2:34][O:35][CH2:36][CH2:37]3)=[CH:27][CH:26]=2)=[CH:17][CH:16]=1)=[O:50]

Participants

4

Reactant 3

HCID 99124171-(5-Tert-butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-ureaHCID 102679534-[5-(4-Aminonaphthyl)pyridin-2-ylmethyl]morpholineHCID 225738682-Methoxy-5-trimethylsilanyl-phenylamine

Product 1

HCID 22573874HCID 22573874, compound

Procedure

The title compound was prepared from the above amine and 4-[5-(4-aminonaphthyl)pyridin-2-ylmethyl]morpholine by the procedure described for 1-(5-tert-butyl-2-methoxy-phenyl)-3-[4-(2-cyano-pyrimidin-4-yloxy)-naphthalen-1-yl]-urea (Example 1).

Sources & evidence

ORD record
ord-e5416358068e4bdd94f94f09ac3542c4
Source dataset
uspto-grants-2005_02
Patent number
US06852717B2

Reaction notes

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