Ethanol → HCID 59380419, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-({3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}amino)[1]benzothieno[2,3-d]pyrimidin-7-ol (150 mg, 0.33 mmol) in EtOH (15 mL) was added (2,3-epoxypropyl)phthalimide (101.2 mg, 0.50 mmol, 1.5 equiv) and triethylamine (1.68 mg, 0.02 mmol, 0.05 equiv) under nitrogen. The reaction mixture was stirred at 80° C. for 15 h and then cooled to rt. The resulting mixture was concentrated in vacuo. The crude material (216 mg, 0.33 mmol) was directly used in the next step without further purification, LCMS RT=3.89 min, [M+H]+=655.1.

Provenance & Evidence