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HRID2353857

反应详情

EQUATION

反应方程式

HRID 2353857 的结构方程式

REACTANTS

反应物

2
结构：CCOC(=O)CCCBr
HCID76300

Ethyl 4-bromobutyrate

C6H11BrO2

结构：COC(=O)c1ccccc1NS(=O)(=O)c1ccc(C)cc1
HCID737605

2-(Toluene-4-sulfonylamino)-benzoic acid methyl ester

C15H15NO4S

PRODUCTS

生成物

1
结构：CCOC(=O)CCCN(c1ccccc1C(=O)OC)S(=O)(=O)c1ccc(C)cc1
HCID266879

Methyl 2-[(4-ethoxy-4-oxobutyl)(4-methylbenzene-1-sulfonyl)amino]benzoate

C21H25NO6S

收率 65%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCC(C)=O
溶剂HCID6569

Methyl ethyl ketone

C4H8O

PROCEDURE

实验过程

A mixture of 2-(Toluene-4-sulfonylamino)-benzoic acid methyl ester (1000 g, 3.27 mol), ethyl 4-bromobutyrate (639 g, 3.45 mol) in 2-butanone (5.6 L) was heated at reflux for 24 hours. After the reaction was completed, the mixture was poured into ice-water, and the resultant precipitates were collected by filtration. The filtrates were washed with ethyl acetate to give 2-[(3-Ethoxycarbonyl-propyl)-(toluene-4-sulfonyl)-amino]-benzoic acid methyl ester (890 g, 65%).

WORKUP

后处理

  1. temperaturewas heated
  2. temperatureat reflux for 24 hours
  3. customthe resultant precipitates
  4. filtrationwere collected by filtration
  5. washThe filtrates were washed with ethyl acetate