HCID 59003120, compound → Isopropyl 5-[Acetyl-(3,5-bis-trifluoromethyl-benzyl)-amino]-9-dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylate

HRID 2353901Notes

Reaction equation

HRID 2353901 reaction equation
C(N(CC1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1)C1CCCN(C(OC(C)C)=O)C2C(Br)=CC=CC1=2)(=O)C.[C:38]([N:41]([CH2:63][C:64]1[CH:69]=[C:68]([C:70]([F:73])([F:72])[F:71])[CH:67]=[C:66]([C:74]([F:77])([F:76])[F:75])[CH:65]=1)[CH:42]1[CH2:48][CH2:47][CH2:46][N:45]([C:49]([O:51][CH:52]([CH3:54])[CH3:53])=[O:50])[C:44]2[CH:55]=[C:56](Cl)[C:57]([N:59]([CH3:61])[CH3:60])=[CH:58][C:43]1=2)(=[O:40])[CH3:39]>>[C:38]([N:41]([CH2:63][C:64]1[CH:69]=[C:68]([C:70]([F:71])([F:73])[F:72])[CH:67]=[C:66]([C:74]([F:76])([F:77])[F:75])[CH:65]=1)[CH:42]1[CH2:48][CH2:47][CH2:46][N:45]([C:49]([O:51][CH:52]([CH3:53])[CH3:54])=[O:50])[C:58]2[C:57]([N:59]([CH3:60])[CH3:61])=[CH:56][CH:55]=[CH:44][C:43]1=2)(=[O:40])[CH3:39]

Participants

3

Reactant 2

HCID 59003120HCID 59003120, compoundHCID 59003164Isopropyl 5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-9-bromo-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate

Product 1

HCID 59003119Isopropyl 5-[Acetyl-(3,5-bis-trifluoromethyl-benzyl)-amino]-9-dimethylamino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carboxylate

Procedure

This compound prepared utilizing the same methodology described in Example 50 wherein replacement of isopropyl-5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-7-bromo-8-chloro-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate with isopropyl 5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-9-bromo-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate following the procedure of Example 50 for the synthesis of isopropyl 5-[acetyl-(3,5-bistrifluoromethylbenzyl)amino]-8-chloro-7-dimethylamino-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate. CI MS 560 (M+H).

Workup

  1. customThis compound prepared

Sources & evidence

ORD record
ord-0bc35e1f1bf94a75a8482f7b0a77c31b
Source dataset
uspto-grants-2010_07
Patent number
US07749992B2

Reaction notes

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