Isopropyl 6-fluoro-7-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate → 9-oxo-2,3,6,7,8,9-hexahydro-1H-5-aza-cyclohepta[f]indene-5-carboxylic acid isopropyl ester
Reaction equation
F[C:2]1[C:12]2[C:11](=[O:13])[CH2:10][CH2:9][CH2:8][N:7]([C:14]([O:16][CH:17]([CH3:19])[CH3:18])=[O:15])[C:6]=2[CH:5]=[CH:4][C:3]=1[CH3:20].CO[C:23]([C:25]1C=C2C(=CC=1N)CCC2)=O>>[CH:17]([O:16][C:14]([N:7]1[C:6]2[C:12](=[CH:2][C:3]3[CH2:20][CH2:23][CH2:25][C:4]=3[CH:5]=2)[C:11](=[O:13])[CH2:10][CH2:9][CH2:8]1)=[O:15])([CH3:19])[CH3:18]Participants
3
Procedure
The titled compound was prepared following the procedure described for the preparation of isopropyl 6-fluoro-7-methyl-5-oxo-2,3,4,5-tetrahydrobenzo[b]azepine-1-carboxylate (example 132, from step 3 to 5) by replacing methyl 2-amino-6-fluoro-5-methylbenzoate with 6-Amino-indan-5-carboxylic acid methyl ester in example 132 step 3. MS (ES+): 288 (M+H).
Sources & evidence
- ORD record
- ord-3ae9be408750461e82760740cd2d4356
- Source dataset
- uspto-grants-2010_07
- Patent number
- US07749992B2
Reaction notes
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