HRID2353961

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)C)c2c1cc(C)c1c2CCC1

HCID59003195

未命名化合物

HCID59379136

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(C(=O)OC(C)C)c2c1cc1c(c2C)CCC1

HCID59003178

未命名化合物

PROCEDURE

实验过程

The titled compound was prepared following the procedures described for the preparation of (+/−)-6-[Acetyl-(3,5-bis-trifluoromethyl-benzyl)-amino]-4-methyl-2,3,6,7,8,9-hexahydro-1H-10-aza-cyclohepta[e]indene-10-carboxylic acid isopropyl ester (example 137) by replacing 4-amino-indan-5-carboxylic acid methyl ester by 6-amino-indan-5-carboxylic acid methyl ester in example 136 step 1.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cb59a3724da5472cbddd80c171fe522d
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07749992B2
来源说明: uspto-grants-2010_07

反应 SMILES

[CH:1]([O:4][C:5]([N:7]1[C:13]2[C:14]3[CH2:15][CH2:16][CH2:17][C:18]=3[C:19]([CH3:21])=[CH:20][C:12]=2[CH:11]([N:22]([C:38](=[O:40])[CH3:39])[CH2:23][C:24]2[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[C:26]([C:34]([F:37])([F:36])[F:35])[CH:25]=2)[CH2:10][CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].COC(C1C=C2C(=CC=1N)CCC2)=O>>[CH:1]([O:4][C:5]([N:7]1[C:13]2[C:12](=[CH:20][C:19]3[CH2:21][CH2:16][CH2:17][C:18]=3[C:14]=2[CH3:15])[CH:11]([N:22]([C:38](=[O:40])[CH3:39])[CH2:23][C:24]2[CH:29]=[C:28]([C:30]([F:32])([F:33])[F:31])[CH:27]=[C:26]([C:34]([F:35])([F:37])[F:36])[CH:25]=2)[CH2:10][CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]