Methyl chloroformate → HCID 59003146, compound

HRID 2353985Notes

Reaction equation

[F:1][C:2]([F:40])([F:39])[C:3]1[CH:4]=[C:5]([CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=1)[CH2:6][N:7]([CH:11]1[CH2:17][CH2:16][CH2:15][N:14]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])[C:13]2[CH:28]=[CH:29][CH:30]=[CH:31][C:12]1=2)C(=O)C.Cl[C:42]([O:44][CH3:45])=[O:43]>>[CH3:45][O:44][C:42](=[O:43])[N:7]([CH2:6][C:5]1[CH:4]=[C:3]([C:2]([F:1])([F:39])[F:40])[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=1)[CH:11]1[CH2:17][CH2:16][CH2:15][N:14]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)(=[O:19])=[O:20])[C:13]2[CH:28]=[CH:29][CH:30]=[CH:31][C:12]1=2

Participants

Reactant 2

HCID 6586Methyl chloroformate

HCID 59003141HCID 59003141, compound

Product 1

HCID 59003146HCID 59003146, compound

Procedure

The titled compound was prepared following the procedures described for the preparation of (+/−) N-(3,5-Bis-trifluoromethyl-benzyl)-N-[1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetamide (example 191, step 3) by replacing acetic anhydride with methyl chloroformate. MS (ES+): 601(M+H).

Sources & evidence

ORD record: ord-4597cab94b944549982861cda9ef134f
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07749992B2

Reaction notes

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