HRID2353985

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6586

Methyl chlorocarbonate

C2H3ClO2

HCID59003141

未命名化合物

PRODUCTS

产物

HCID59003146

未命名化合物

PROCEDURE

实验过程

The titled compound was prepared following the procedures described for the preparation of (+/−) N-(3,5-Bis-trifluoromethyl-benzyl)-N-[1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepin-5-yl]-acetamide (example 191, step 3) by replacing acetic anhydride with methyl chloroformate. MS (ES+): 601(M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-4597cab94b944549982861cda9ef134f
来源数据集: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US07749992B2
来源说明: uspto-grants-2010_07

反应SMILES

[F:1][C:2]([F:40])([F:39])[C:3]1[CH:4]=[C:5]([CH:32]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:34]=1)[CH2:6][N:7]([CH:11]1[CH2:17][CH2:16][CH2:15][N:14]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])[C:13]2[CH:28]=[CH:29][CH:30]=[CH:31][C:12]1=2)C(=O)C.Cl[C:42]([O:44][CH3:45])=[O:43]>>[CH3:45][O:44][C:42](=[O:43])[N:7]([CH2:6][C:5]1[CH:4]=[C:3]([C:2]([F:1])([F:39])[F:40])[CH:34]=[C:33]([C:35]([F:38])([F:37])[F:36])[CH:32]=1)[CH:11]1[CH2:17][CH2:16][CH2:15][N:14]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH3:27])=[CH:23][CH:22]=2)(=[O:19])=[O:20])[C:13]2[CH:28]=[CH:29][CH:30]=[CH:31][C:12]1=2