HCID 178420349, compound → HCID 178511574, compound

HRID 2354006Notes

Reaction equation

HRID 2354006 reaction equation
C([N:8](CC1C=CC=CC=1)[C@H:9]1[CH2:14][CH2:13][C@H:12]([N:15]2[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:11][CH2:10]1)C1C=CC=CC=1>CO.[Pd]>[N:15]1([C@H:12]2[CH2:11][CH2:10][C@H:9]([NH2:8])[CH2:14][CH2:13]2)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

4

Reactant 1

HCID 178420349HCID 178420349, compound

Product 1

HCID 178511574HCID 178511574, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

1.7 g (4.8 mmol) of trans-dibenzyl-4-piperidino-cyclohexylamine were dissolved in 35 mL MeOH and hydrogenated on 350 mg of Pd/C (10%) at 20° C. The solvent was eliminated in vacuo and the residue crystallised from ethanol and conc. HCl. Yield: 1.1 g (78%).

Workup

  1. customthe residue crystallised from ethanol and conc. HCl

Sources & evidence

ORD record
ord-e400ee3184e647ceb04f1d690e4495c0
Source dataset
uspto-grants-2010_07
Patent number
US07750152B2

Reaction notes

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