Pyridinium chloride → HCID 10483384, compound

HRID 2354022Notes

Reaction equation

HRID 2354022 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([CH3:34])=[N:25][C:26]([CH3:33])=[CH:27][C:28]=2[C:29]([F:32])([F:31])[F:30])=[O:21])[CH2:15][CH2:14]1.[ClH:35].N1C=CC=CC=1>C(O)C>[ClH:35].[ClH:35].[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([CH3:34])=[N:25][C:26]([CH3:33])=[CH:27][C:28]=2[C:29]([F:32])([F:31])[F:30])=[O:21])[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 10483385HCID 10483385, compound

Product 1

HCID 10483384HCID 10483384, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-[2-(benzothiazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,6-dimethyl-4-trifluoromethyl-3-pyridyl]acetamide (500 mg, 0.98 mmol) was dissolved in ethanol (10 mL), followed by the addition of pyridine hydrochloride (227 mg, 1.96 mmol). The reaction mixture was concentrated, and to the residue, ethanol (0.2 mL) and water (2 mL) were added. A precipitate was collected by filtration to obtain the title compound (295 mg, 55%) as a colorless crystalline powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue, ethanol (0.2 mL) and water (2 mL) were added
  3. filtrationA precipitate was collected by filtration

Sources & evidence

ORD record
ord-eba236a1947f46dd9e3ff9ad112140eb
Source dataset
uspto-grants-2010_07
Patent number
US07750150B2

Reaction notes

Loading…