Pyridinium chloride → HCID 67128195, compound

HRID 2354024Notes

Reaction equation

HRID 2354024 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([O:36][CH2:37][CH2:38][O:39][CH3:40])=[N:25][C:26]([CH3:35])=[CH:27][C:28]=2[O:29][CH2:30][C:31]([F:34])([F:33])[F:32])=[O:21])[CH2:15][CH2:14]1.[ClH:41].N1C=CC=CC=1>C(O)C>[ClH:41].[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[C:2]1[S:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][C:20]([NH:22][C:23]2[C:24]([O:36][CH2:37][CH2:38][O:39][CH3:40])=[N:25][C:26]([CH3:35])=[CH:27][C:28]=2[O:29][CH2:30][C:31]([F:32])([F:33])[F:34])=[O:21])[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 10176127Pyridinium chlorideHCID 23110959HCID 23110959, compound

Product 1

HCID 67128195HCID 67128195, compoundYield 25.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-[4-[2-(Benzoxazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2-(2-methoxyethoxy)-4-(2,2,2-trifluoroethoxy)-6-methyl-3-pyridyl]acetamide (500 mg, 0.86 mmol) was dissolved in ethanol (10 mL), followed by the addition of pyridine hydrochloride (198 mg, 1.71 mmol). The reaction mixture was concentrated, and to the residue, ethanol (0.2 mL) and water (2 mL) were added. A precipitate was collected by filtration to afford the title compound (134 mg, 25.2%) as a colorless crystalline powder.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue, ethanol (0.2 mL) and water (2 mL) were added
  3. filtrationA precipitate was collected by filtration

Sources & evidence

ORD record
ord-0dec4eb73a644020a7da8f0a9bd6502d
Source dataset
uspto-grants-2010_07
Patent number
US07750150B2

Reaction notes

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