HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Cyclohexanedione → SS-3227
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Cyclohexanedione | HCID 12511 | — |
| Reactant | 4-[4-(Trifluoromethoxy)phenoxy]piperidine | HCID 16115439 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | SS-3227 | HCID 11653258 | 43.9% |
Reaction Steps
261 mg of 4-(4-trifluoromethoxyphenoxy)piperidine and 224 mg of 1,4-cyclohexanedione were heated under reflux in 5 ml of ethanol and reacted for 7 hours. After concentrating the reaction mixture under reduced pressure, the resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=3:1) and 154.9 mg of 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine was obtained (yield 43.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750156B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-aa7d2389db274cffb495e44e394fa6c5 |
| Source note | uspto-grants-2010_07 |