HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Cyclohexanedione → SS-3227
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Cyclohexanedione | HCID 12511 | — |
| Reactant | 4-[4-(Trifluoromethoxy)phenoxy]piperidine | HCID 16115439 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | SS-3227 | HCID 11653258 | 89.2% |
Reaction Steps
261 mg of 4-(4-trifluoromethoxyphenoxy)piperidine, 224 mg of 1,4-cyclohexanedione and 4 mg of 10% palladium-carbon were heated in ethanol and reacted at 70° C. to 80° C. for 9 hours. After the completion of the reaction, the resultant was separated by silica gel column chromatography (n-hexane:ethyl acetate=3:1) and 315 mg of 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine was obtained (yield 89%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07750156B2 |
| Source dataset | uspto-grants-2010_07 |
| ORD ID | ord-f9df210fb59f4c119e3d972a10caa7f3 |
| Source note | uspto-grants-2010_07 |