反应详情

温度

0 °C

A solution of 4-[ethyl-(4-methoxy-benzenesulfonyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester (11.1 g, 28 mmol) in CH2Cl2 (50 mL) is cooled at 0° C. and TFA (40 mL) is added. The mixture is stirred at 0° C. for 0.5 h and then evaporated. The residue is dissolved in CH2Cl2 (50 mL) and 1 M aq. NaOH (50 mL) is added. The mixture is stirred for 15 h at r.t., then the phases are separated and the aq. phase is extracted with CH2Cl2 (4×30 mL). The combined org. phases are washed with 1 M aq. NaOH (2×30 mL), dried (Na2SO4), filtered and evaporated to provide the title compound.

1. customevaporated
2. dissolutionThe residue is dissolved in CH2Cl2 (50 mL)
3. addition1 M aq. NaOH (50 mL) is added
4. stirringThe mixture is stirred for 15 h at r.t.
5. customthe phases are separated
6. extractionthe aq. phase is extracted with CH2Cl2 (4×30 mL)
7. washphases are washed with 1 M aq. NaOH (2×30 mL)
8. dry with materialdried (Na2SO4)
9. filtrationfiltered
10. customevaporated