Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-6-methylpyridine-4-carboxylic acid | HCID 141209 | — |
| Reactant | Styrylboronic acid | HCID 5702628 | — |
| Catalyst | HCID 178418807 | HCID 178418807 | — |
| Solvent | Acetonitrile--water (1/1) | HCID 18373917 | — |
| Product | HCID 68693732 | HCID 68693732 | — |
Reaction Steps
A suspension of 2-chloro-6-methyl-isonicotinic acid (171.6 mg, 1 mmol), (E)-2-phenyl-etheneboronic acid (180.0 mg, 1.2 mmol), K2CO3 (414 mg), Pd(dppf)Cl2-CH2Cl2 (27 mg) in CH3CN—H2O (3:1, 10 mL) is stirred under argon at 90° C. for 15 h. The solution is cooled to r.t. and aq. hydrochloric acid (2 M, 1.5 mL) is added to adjust the pH at 3. The mixture is evaporated to dryness and purified by reversed phase MPLC to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07750161B2 |
|---|
| Source dataset | uspto-grants-2010_07 |
|---|
| ORD ID | ord-8fb8509910584883ad235b36d1bfcf3d |
|---|
| Source note | uspto-grants-2010_07 |
|---|
