HCID 53637388, compound → HCID 55285766, compound

Participants

Reaction Conditions

Reaction Steps

2-Ethyl-6-methyl-4-nitro-pyridine 1-oxide (27.65 g, 151.8 mmol) is dissolved in AcOH (330 mL) and Fe (powder, 33.9 g) is added. The mixture is stirred for 1 h at 100° C. The mixture is cooled to r.t. and filtered. The filtercake is thoroughly washed with AcOH and then discarded. The filtrate is evaporated, diluted with water (100 mL), basified (pH>10) with NaOH (1 M, 100 mL), filtered from the formed precipitate and the filtrate is extracted with CH2Cl2 (10×75 mL). The combined organic extracts are dried (MgSO4), filtered and evaporated to provide the title compound.

Provenance & Evidence