Ethyl isocyanatoacetate → HCID 58816583, compound

Participants

Reaction Steps

2-Methyl-pyridin-4-ylamine (1.08 g, 10 mmol) is dissolved in dry THF (30 mL) and isocyanatoacetic acid ethyl ester (1.29 g, 10 mmol) is added. The mixture is stirred at r.t. for 15 h. The mixture is evaporated and 6N aq. HCl (20 mL) is added. The mixture is stirred at 50° C. for 6 h, evaporated and the residue purified by reversed phase MPLC to provide the title compound.

Provenance & Evidence