反应详情

A mixture of 4-(tert-butoxycarbonyl-methyl-amino)-piperidine-1-carboxylic acid benzyl ester (17.5 mmol) and Pd—C (10%, 500 mg) in MeOH (150 mL) hydrogenated at atm. pressure and r.t. for 15 h. The mixture is filtered and evaporated. The residue is dissolved in CH2Cl2 (100 mL) and 1 M aq. NaOH (50 mL) is added. The mixture is stirred for 6 h at r.t., then the phases are separated and the aq. phase is extracted with CH2Cl2 (3×50 mL). The combined organic extracts are dried (Na2SO4), filtered and evaporated to provide the title compound.

1. filtrationThe mixture is filtered
2. customevaporated
3. dissolutionThe residue is dissolved in CH2Cl2 (100 mL)
4. addition1 M aq. NaOH (50 mL) is added
5. customthe phases are separated
6. extractionthe aq. phase is extracted with CH2Cl2 (3×50 mL)
7. dry with materialThe combined organic extracts are dried (Na2SO4)
8. filtrationfiltered
9. customevaporated