Sodium Iodide → (1-{2-[3-(2,6-Dimethyl-pyridin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-methyl-carbamic acid tert-butyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Iodide	HCID 5238	—
반응물	Sodium Bicarbonate	HCID 516892	—
반응물	4-N-Boc-4-N-Methyl-aminopiperidine	HCID 2756806	—
반응물	1-(2-Chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea	HCID 58816567	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	(1-{2-[3-(2,6-Dimethyl-pyridin-4-yl)-ureido]-ethyl}-piperidin-4-yl)-methyl-carbamic acid tert-butyl ester	HCID 68690307	—

반응 조건

온도	50 °C

반응 단계

A suspension of methyl-piperidin-4-yl-carbamic acid tert-butyl ester (3.57 g, 16.7 mmol), NaHCO3 (6.7 g, 79 mmol), NaI (1.5 g, 10 mmol) and 1-(2-chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea (Example D1, 2.14 g 9.4 mmol) in THF (30 mL) is stirred at 50° C. for 14 days. The mixture is quenched with Na2CO3 (50 mL) and extracted with CH2Cl2 (5×50 mL). The organic extracts are washed with sat. aq. Na2CO3 (30 mL), dried (Na2SO4), filtered and evaporated. The residue is purified by FC to provide the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07750161B2
출처 데이터셋	uspto-grants-2010_07
ORD ID	ord-1b496d75bbb24013afbe7cf37c2bc6be
출처 메모	uspto-grants-2010_07