1,2-Dichloroethane → HCID 68690135, compound

Participants

Reaction Steps

To a cooled (0° C.) mixture of [3-(2-methyl-pyridin-4-yl)-ureido]-acetic acid (Example D3., 105 mg, 0.5 mmol), 4-benzylpiperidine (Example A1., 105 mg, 0.6 mmol), HOBt (81 mg, 0.6 mmol), TEA (0.14 mL, 1 mmol) and a cat. amount of DMAP in CH2Cl2 (20 mL) are added, followed by EDC (115 mg, 0.6 mmol). The mixture is stirred at r.t. for 15 h. The mixture is quenched with sat. aq. Na2CO3 (25 mL), the phases are separated, and the aq. phase is extracted with CH2Cl2 (3×30 mL). The combined organic extracts are dried (Na2SO4), filtered and evaporated to provide the crude title compound.

Provenance & Evidence