Benzenesulfonyl chloride → HCID 58816575, compound

HRID 2354083Notes

Reaction equation

HRID 2354083 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]([NH:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][CH3:21])[CH2:16][CH2:15]2)=[O:10])[CH:5]=[C:4]([CH3:22])[N:3]=1.[C:23]1([S:29](Cl)(=[O:31])=[O:30])[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>C(Cl)Cl>[CH3:22][C:4]1[CH:5]=[C:6]([NH:8][C:9](=[O:10])[NH:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([N:20]([CH3:21])[S:29]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)(=[O:31])=[O:30])[CH2:16][CH2:15]2)[CH:7]=[C:2]([CH3:1])[N:3]=1

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 58816577HCID 58816577, compound

Product 1

HCID 58816575HCID 58816575, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a cooled (0° C.) mixture of 1-(2,6-dimethyl-pyridin-4-yl)-3-[2-(4-methylamino-piperidin-1-yl)-ethyl]-urea (Example E1., 0.3 mmol) and TEA (0.5 mL, 0.35 mmol) in CH2Cl2 (2 mL) is added a solution of benzenesulfonyl chloride (53.0 mg, 0.3 mmol) in CH2Cl2 (1 mL). The mixture is stirred at r.t. for 15 h and evaporated. the residue is purified by HPLC to provide the title compound.

Workup

  1. temperatureTo a cooled
  2. customevaporated
  3. customthe residue is purified by HPLC

Sources & evidence

ORD record
ord-35984cbcd8094763ac4feef8fa2366d8
Source dataset
uspto-grants-2010_07
Patent number
US07750161B2

Reaction notes

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