Hydrochloric Acid → HCID 67128803, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl (2E)-3-[5-({(3R)-1-[2-(3-fluorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylate (235 mg) and 1N—NaOH aq. (1.3 mL) in MeOH (4.7 mL) was heated at 50° C. for 3 hours. After cooling, 1N—HCl (1.37 mL) was added to the solution. The mixture was evaporated and azeotroped with dioxane and toluene to give a crude (2E)-3-[5-({(3R)-1-[2-(3-fluorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]acrylic acid (226 mg).

Provenance & Evidence