Hydrochloric Acid → HCID 135900411, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (2E)-3-[5-({(3R)-1-[2-(2-chlorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (95 mg) in EtOH (1 mL) was added a 2N—HCl solution in EtOH (0.5 mL) and the mixture was stirred at 20-25° C. for 2 hours. After removal of EtOH by evaporation, IPE (2 mL) was added to the mixture to give a solid. The solid was collected by filtration and dried under reduced pressure to give (2E)-3-[5-({(3R)-1-[2-(2-chlorophenyl)ethyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-hydroxyacrylamide dihydrochloride (86 mg).

Provenance & Evidence