Acetone → HCID 135900427, compound

Participants

Reaction Steps

To a solution of (2E)-3-[5-({(3R)-1-[2-methyl-2-phenylpropyl]-3-pyrrolidinyl}amino)-2-pyrazinyl]-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (130 mg) in EtOH (0.7 mL) was added 2N—HCl solution in EtOH (0.7 mL) and the reaction mixture was stirred for 2 hours at ambient temperature. Acetone was added to the mixture and filtered. The filtrate was evaporated and dried to give (2E)-N-hydroxy-3-[5-[{(3R)-1-(2-methyl-2-phenylpropyl)-3-pyrrolidinyl}amino]-2-pyrazinyl]acrylamide dihydrochloride (108 mg).

Provenance & Evidence