[4-Amino-2-(methylsulfanyl)pyrimidin-5-yl]methanol → 4-Amino-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

Participants

Reaction Steps

To the solution of 4-amino-5-hydroxymethyl-2-(methylthio)pyrimidine (1-1; 1.0 g, 5.84 mmol) in CHCl3 (100 mL) was added MnO2(2.5 g, 29.2 mmol, 5 equiv). The suspension was stirred at rt overnight. The mixture was filtered through celite and washed with CHCl3. The combined filtrate was concentrated to give the titled compound (1-2). 1H-NMR (500 MHz, CDCl3) δ 9.78 (s, 1H), 8.42 (s, 1H), 8.20 (broad, 1H), 5.74 (broad, 1H)), 2.55 (3, 3H).

Provenance & Evidence