Potassium Hydroxide → 3',4'-Dichloro-5-fluoro-[1,1'-biphenyl]-2-amine

Participants

Reaction Conditions

Reaction Steps

0.08 mol of an approximately 45% aqueous potassium hydroxide solution is added to a suspension of 6.3 g (0.02 mol, purity: 95%) N-(3′,4′-dichloro-5-fluorobiphenyl-2-yl)acetamide and 12 ml 2-methoxyethanol. This is heated to 100° C., stirred for 4 hours, cooled and the solvent is distilled off in a vacuum. The residue is mixed with ice water and extracted several times with toluene.

Provenance & Evidence