反应详情

Benzphetamine hydrochloride is prepared in typical fashion in toluene. After reaction of methamphetamine with benzyl chloride in the presence of sodium carbonate, the reaction mass contained 28.76 g (0.1202 mole) of the acid salt which was a yield of 82.5%. To the reaction mass were added 100 g of deionized water. The mixture was stirred to dissolve the salts and then transferred to a separatory funnel. The reaction flask was rinsed with 50 g of water and 65 g of toluene. The rinsings were added to the separatory funnel. The layers were separated into a 169.5 g water layer and a 104.2 g of organic layer. The water layer was extracted twice with 27 g portions of toluene. The organic layers were combined bringing the total amount of organic medium to 156.1 g. The combined toluene portions were then washed with 33 g of deionized water.

1. dissolutionto dissolve the salts
2. customtransferred to a separatory funnel
3. washThe reaction flask was rinsed with 50 g of water and 65 g of toluene
4. additionThe rinsings were added to the separatory funnel
5. customThe layers were separated into a 169.5 g water layer
6. extractionThe water layer was extracted twice with 27 g portions of toluene
7. washThe combined toluene portions were then washed with 33 g of deionized water