1-Ethylpiperazine → HCID 69564789, 화합물

HRID 2354150노트

반응식

HRID 2354150 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1)[CH3:2].Cl[C:10]1[CH:11]=[CH:12][C:13]([N+:32]([O-:34])=[O:33])=[C:14]([CH:31]=1)[C:15]([NH:17][C:18]1[CH:23]=[C:22]([C:24]([NH:26][CH:27]2[CH2:29][CH2:28]2)=[O:25])[CH:21]=[CH:20][C:19]=1[CH3:30])=[O:16]>>[CH:27]1([NH:26][C:24]([C:22]2[CH:21]=[CH:20][C:19]([CH3:30])=[C:18]([NH:17][C:15](=[O:16])[C:14]3[CH:31]=[C:10]([N:6]4[CH2:7][CH2:8][N:3]([CH2:1][CH3:2])[CH2:4][CH2:5]4)[CH:11]=[CH:12][C:13]=3[N+:32]([O-:34])=[O:33])[CH:23]=2)=[O:25])[CH2:29][CH2:28]1

참가 물질

3

반응물 2

HCID 791961-EthylpiperazineHCID 69572773HCID 69572773, 화합물

생성물 1

HCID 69564789HCID 69564789, 화합물

실험 절차

Using an analogous procedure to that described paragraph (B) in the portion of Example 1, which is concerned with the preparation of starting materials, N-ethylpiperazine was reacted with 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-(4-ethylpiperazine-1-yl)-2-nitrobenzamide; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.67 (m, 2H), 1.02 (t, 3H), 2.30 (s, 3H), 2.37 (m, 2H), 2.48 (m, 4H), 2.83 (m, 1H), 3.49 (m, 4H), 7.06 (m, 2H), 7.28 (d, 1H), 7.56 (d, 1H), 7.96 (s, 1H), 8.04 (d, 1H), 8.35 (d, 1H), 9.91 (s, 1H);

출처 및 근거

ORD 기록
ord-df665aa1d2ed4dee98d2ff085905949b
출처 데이터셋
uspto-grants-2010_07
특허 번호
US07750154B2

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