1-Isopropylpiperazine → HCID 69566071, compound

HRID 2354151Notes

Reaction equation

HRID 2354151 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].Cl[C:11]1[CH:12]=[CH:13][C:14]([N+:33]([O-:35])=[O:34])=[C:15]([CH:32]=1)[C:16]([NH:18][C:19]1[CH:24]=[C:23]([C:25]([NH:27][CH:28]2[CH2:30][CH2:29]2)=[O:26])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:17]>>[CH:28]1([NH:27][C:25]([C:23]2[CH:22]=[CH:21][C:20]([CH3:31])=[C:19]([NH:18][C:16](=[O:17])[C:15]3[CH:32]=[C:11]([N:7]4[CH2:8][CH2:9][N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6]4)[CH:12]=[CH:13][C:14]=3[N+:33]([O-:35])=[O:34])[CH:24]=2)=[O:26])[CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 780131-IsopropylpiperazineHCID 69572773HCID 69572773, compound

Product 1

HCID 69566071HCID 69566071, compound

Procedure

Using an analogous procedure to that described paragraph (3) in the portion of Example 1 which is concerned with the preparation of starting materials, N-isopropylpiperazine was reacted with 5-chloro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-(4-isopropylpiperazine-1-yl)-2-nitrobenzamide; NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.67 (m, 2H), 0.99 (d, 6H), 2.29 (s, 3H), 2.54 (m, 4H), 2.68 (m, 1H), 2.83 (m, 1H), 3.48 (m, 4H), 7.05 (m, 2H), 7.27 (d, 1H), 7.56 (d, 1H), 7.96 (s, 1H), 8.03 (d, 1H), 8.35 (d, 1H), 9.90 (s, 1H); Mass Spectrum M+H+ 466.

Sources & evidence

ORD record
ord-62a3dc93203644e7a2fec9c5cbd35e96
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

Loading…