tert-Butyl (piperazin-1-yl)acetate → HCID 123579949, compound

HRID 2354157Notes

Reaction equation

HRID 2354157 reaction equation
[N:1]1([CH2:7][C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[CH:15]1([NH:18][C:19]([C:21]2[CH:22]=[CH:23][C:24]([CH3:40])=[C:25]([NH:27][C:28](=[O:39])[C:29]3[CH:34]=[C:33](F)[CH:32]=[CH:31][C:30]=3[N+:36]([O-:38])=[O:37])[CH:26]=2)=[O:20])[CH2:17][CH2:16]1>>[C:11]([O:10][C:8](=[O:9])[CH2:7][N:1]1[CH2:6][CH2:5][N:4]([C:33]2[CH:32]=[CH:31][C:30]([N+:36]([O-:38])=[O:37])=[C:29]([C:28]([NH:27][C:25]3[CH:26]=[C:21]([C:19]([NH:18][CH:15]4[CH2:17][CH2:16]4)=[O:20])[CH:22]=[CH:23][C:24]=3[CH3:40])=[O:39])[CH:34]=2)[CH2:3][CH2:2]1)([CH3:14])([CH3:13])[CH3:12]

Participants

3

Reactant 2

HCID 2757326tert-Butyl (piperazin-1-yl)acetateHCID 669189745-fluoro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide

Product 1

HCID 123579949HCID 123579949, compound

Procedure

Using an analogous procedure to that described paragraph (B) in the portion of Example 1 which is concerned with the preparation of starting materials, tert-butyl piperazin-1-ylacetate was reacted with N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-fluoro-2-nitrobenzamide to give tert-butyl(4-{3-[({5-[(cyclopropylamino)carbonyl]-2-methylphenyl}amino)carbonyl]-4-nitrophenyl}piperazin-1-yl)acetate; NMR Spectrum: (DMSOd6) 0.58 (m, 2H), 0.70 (m, 2H), 1.43 (s, 9H), 2.32 (s, 3H), 2.66 (m, 4H), 2.86 (m, 1H), 3.21 (s, 2H), 3.53 (m, 4H), 7.09 (m, 2H), 7.30 (m, 1H), 7.59 (m, 1H), 7.99 (s, 1H), 8.07 (m, 1H), 8.38 (m, 1H), 9.93 (s, 1H); Mass Spectrum: M+H+ 538.

Sources & evidence

ORD record
ord-a3cf66a9c6d9478697594b8e31291ef1
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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