1-(Methylsulfonyl)piperazine → HCID 69564861, compound

HRID 2354160Notes

Reaction equation

HRID 2354160 reaction equation
[CH3:1][S:2]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].[CH:11]1([NH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([CH3:36])=[C:21]([NH:23][C:24](=[O:35])[C:25]3[CH:30]=[C:29](F)[CH:28]=[CH:27][C:26]=3[N+:32]([O-:34])=[O:33])[CH:22]=2)=[O:16])[CH2:13][CH2:12]1>>[CH:11]1([NH:14][C:15]([C:17]2[CH:18]=[CH:19][C:20]([CH3:36])=[C:21]([NH:23][C:24](=[O:35])[C:25]3[CH:30]=[C:29]([N:8]4[CH2:9][CH2:10][N:5]([S:2]([CH3:1])(=[O:4])=[O:3])[CH2:6][CH2:7]4)[CH:28]=[CH:27][C:26]=3[N+:32]([O-:34])=[O:33])[CH:22]=2)=[O:16])[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 7091611-(Methylsulfonyl)piperazineHCID 669189745-fluoro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide

Product 1

HCID 69564861HCID 69564861, compound

Procedure

Using an analogous procedure to that described paragraph (13) in the portion of Example 1 which is concerned with the preparation of starting materials, 1-(methylsulfonyl)piperazine was reacted with N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-fluoro-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-[4-(methylsulfonyl)piperazin-1-yl]-2-nitrobenzamide; NMR Spectrum: (DMSOd6) 0.64 (m, 4H), 2.31 (s, 3H), 2.84 (m, 1H), 2.93 (s, 3H), 3.26 (m, 4H), 3.64 (m, 4H), 7.13 (m, 2H), 7.29 (d, 1H), 7.58 (d, 1H), 7.98 (s, 1H), 8.08 (t, 1H), 8.37 (d, 1H), 9.95 (s, 1H); Mass Spectrum: M−H+ 500.

Sources & evidence

ORD record
ord-3ba378f1eb8944848ffc334d9362111c
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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