Thiomorpholine → HCID 66918648, compound

HRID 2354177Notes

Reaction equation

HRID 2354177 reaction equation
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][CH2:2]1.[CH:7]1([NH:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]([CH3:32])=[C:17]([NH:19][C:20](=[O:31])[C:21]3[CH:26]=[C:25](F)[CH:24]=[CH:23][C:22]=3[N+:28]([O-:30])=[O:29])[CH:18]=2)=[O:12])[CH2:9][CH2:8]1>>[CH:7]1([NH:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]([CH3:32])=[C:17]([NH:19][C:20](=[O:31])[C:21]3[CH:26]=[C:25]([N:1]4[CH2:6][CH2:5][S:4][CH2:3][CH2:2]4)[CH:24]=[CH:23][C:22]=3[N+:28]([O-:30])=[O:29])[CH:18]=2)=[O:12])[CH2:9][CH2:8]1

Participants

3

Reactant 2

HCID 67164ThiomorpholineHCID 669189745-fluoro-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitrobenzamide

Product 1

HCID 66918648HCID 66918648, compound

Procedure

Using an analogous procedure to that described paragraph (A) in the portion of Example 13 which is concerned with the preparation of starting materials thiomorpholine was reacted with N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-fluoro-2-nitrobenzamide to give N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-nitro-5-thiomorpholin-4-ylbenzamide; NMR Spectrum: (DMSOd6) 0.56 (m, 2H), 0.67 (m, 2H), 2.30 (s, 3H), 2.67 (m, 4H), 2.82 (m, 1H), 3.91 (m, 4H), 7.06 (m, 2H), 7.27 (d, 1H), 7.55 (d, 1H), 7.97 (s, 1H), 8.04 (d, 1H), 8.37 (s, 1H), 9.90 (s, 1H); Mass Spectrum: M+Na+ 463.

Sources & evidence

ORD record
ord-cb74d0f8ab404a41801e6dfa558c6355
Source dataset
uspto-grants-2010_07
Patent number
US07750154B2

Reaction notes

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