HCID 66918659, compound → HCID 11442511, compound

HRID 2354193Notes

Reaction equation

[CH:1]1([NH:4][C:5]([C:7]2[CH:8]=[CH:9][C:10]([CH3:35])=[C:11]([NH:13][C:14](=[O:34])[C:15]3[CH:20]=[C:19]([O:21][CH:22]4[CH2:27][CH2:26][N:25]([CH:28]5[CH2:30][CH2:29]5)[CH2:24][CH2:23]4)[CH:18]=[CH:17][C:16]=3[N+:31]([O-])=O)[CH:12]=2)=[O:6])[CH2:3][CH2:2]1.N[C:37]1C=CC(OC2CCN(C3CC3)CC2)=CC=1C(NC1C=C(C(NC2CC2)=O)C=CC=1C)=O>>[CH:1]1([NH:4][C:5](=[O:6])[C:7]2[CH:8]=[CH:9][C:10]([CH3:35])=[C:11]([N:13]3[C:14](=[O:34])[C:15]4[C:16](=[CH:17][CH:18]=[C:19]([O:21][CH:22]5[CH2:27][CH2:26][N:25]([CH:28]6[CH2:30][CH2:29]6)[CH2:24][CH2:23]5)[CH:20]=4)[N:31]=[CH:37]3)[CH:12]=2)[CH2:3][CH2:2]1

Participants

Reactant 2

HCID 66918659HCID 66918659, compound

HCID 66919107HCID 66919107, compound

Product 1

HCID 11442511HCID 11442511, compound

Procedure

Using an analogous procedure to that described paragraph (B) in the portion of Example 15 which is concerned with the preparation of starting material, N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-[(1-cyclopropylpiperidine-4-yl)oxy]-2-nitrobenzamide was reduced to 2-amino-N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-5-[(1-cyclopropylpiperidine-4-yl)oxy]benzamide; Mass Spectrum: M+H+ 449.

Sources & evidence

ORD record: ord-215128e70e45477aacc91692f52be55b
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750154B2

Reaction notes

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